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Different classes of nonsteroidal anti-inflammatory drugs, NSAIDs, were separately coated with cationic (E) and anionic (L) Eudragit using the fluidized bed technique. The bioavailability and ulcerogenic activity of coated and uncoated drugs were assessed in rats. The cationic coat decreased the ulcerogenic activity in all classes of NSAIDs and increased the bioavailability only in acidic and enolic ones. The anionic coat, however, increased the bioavailability in basic NSAIDs.
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Meshali et al. (1987) studied this question.
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