What question did this study set out to answer?

To evaluate the efficacy of daily soy isoflavone supplementation on bone mineral density and content in postmenopausal Chinese women.

October 1, 2003The Journal of Clinical Endocrinology & Metabolism

Soy Isoflavones Have a Favorable Effect on Bone Loss in Chinese Postmenopausal Women with Lower Bone Mass: A Double-Blind, Randomized, Controlled Trial

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To evaluate the efficacy of daily soy isoflavone supplementation on bone mineral density and content in postmenopausal Chinese women.
A double-blind, placebo-controlled, randomized trial in 203 postmenopausal women (aged 48–62 yr) assigned to daily placebo (n = 67), mid-dose soy extract (~40 mg isoflavones; n = 68), or high-dose soy extract (~80 mg isoflavones; n = 68) for 1 year.
All participants received co-supplementation with 500 mg calcium and 125 IU vitamin D3 daily; dual energy x-ray absorptiometry measured bone mineral density (BMD) and content (BMC) at baseline and 1 year.
Women in the high-dose group experienced a statistically significantly higher favorable change rate in BMC at the total hip and trochanter (P < 0.05) compared to the placebo and mid-dose groups.
Stratified analyses indicated that the protective effects of soy isoflavones were restricted exclusively to women with baseline BMC at or below the median.

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Implication

Randomized double-blind trial reveals soy isoflavones attenuate hip bone loss in postmenopausal women with low bone mass, suggesting a targeted dietary strategy for skeletal health.

Cite This Study

Chen et al. (2003) studied this question.

synapsesocial.com/papers/6a953992c05e7b5813b2dfc4 https://doi.org/10.1210/jc.2003-030290

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Implication

Randomized double-blind trial reveals soy isoflavones attenuate hip bone loss in postmenopausal women with low bone mass, suggesting a targeted dietary strategy for skeletal health.

Soy Isoflavones Have a Favorable Effect on Bone Loss in Chinese Postmenopausal Women with Lower Bone Mass: A Double-Blind, Randomized, Controlled Trial

Key Points

Discussion

Implication

Cite This Study

Soy Isoflavones Have a Favorable Effect on Bone Loss in Chinese Postmenopausal Women with Lower Bone Mass: A Double-Blind, Randomized, Controlled Trial

Key Points

Discussion

Implication

Cite This Study

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