Clinical investigation reveals reduced pituitary ACTH release alongside preserved adrenal responsiveness in aging men, indicating selective endocrine decline.
The results of this study indicate a decreased acth output of the anterior pituitary in the aged in response to epinephrine administration. The ability of the adrenal cortex to secrete hormones of the 11-17-oxysteroid group under acth stimulation is, however, not grossly impaired in senescence. The renal handling of uric acid in response to adrenal cortical “s” is altered in the aged. This paper was presented in part at the second annual meeting of The Gerontological Society, Inc. in chicago, november 5-6, 1949.
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Solomon et al. (1950) studied this question.
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