Demeclocycline and Therapy of Hyponatremia

Comments1 January 1977Demeclocycline and Therapy of HyponatremiaMALCOLM COX, M.D., JOSEPH GUZZO, M.D., GAIL MORRISON, M.D., IRWIN SINGER, M.D.MALCOLM COX, M.D.Search for more papers by this author, JOSEPH GUZZO, M.D.Search for more papers by this author, GAIL MORRISON, M.D.Search for more papers by this author, IRWIN SINGER, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-1-113 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptTo the editor: Demeclocycline is known to cause nephrogenic diabetes insipidus in humans and to inhibit ADH-induced osmotic water flow in the toad urinary bladder (1). The drug has been used successfully in the treatment of the syndrome of inappropriate antidiuretic hormone secretion (2-4), allowing patients free access to water. Recently De Troyer and colleagues (5) have reported that demeclocycline causes both a water and a sodium diuresis in patients with cirrhosis. However, there was no change in plasma sodium concentration despite the production of a hypotonic urine (mean urine osmolality, 183 mosmol/kg). Even assuming that the patients excreted no urea (that is, attributing all the urine osmolality [Uosm] to electrolytes) and had zero insensible water loss, it is difficult to understand why the plasma...References1. SINGERROTENBERG ID: Demeclocycline-induced nephrogenic diabetes insipidus. In-vivo and in-vitro studies. Ann Intern Med 79:679-683, 1973 LinkGoogle Scholar2. DE TROYERDEMANET AJ: Correction of antidiuresis by demeclocycline. N Engl J Med 293:915-918, 1975 CrossrefMedlineGoogle Scholar3. CHERRILLSTOTEBIRGE DRJ: Demeclocycline treatment in the syndrome of inappropriate antidiuretic hormone secretion. Ann Intern Med 83:654-656, 1975 LinkGoogle Scholar4. FORRESTCOXHONG JMC: Response of the syndrome of inappropriate ADH to declomycin (DMC): superiority of DMC over lithium therapy, in Abstracts of the IXth Meeting of the American Society of Nephrology 1976, in press. Google Scholar5. DE TROYERPILLOYBROECKAERT AWI: Demeclocycline treatment of water retention in cirrhosis. Ann Intern Med 85:336-337, 1976 LinkGoogle Scholar1. DE TROYERPILLOYBROECKAERT AWI: Demeclocycline treatment of water retention in cirrhosis. Ann Intern Med 85:336-337, 1976 LinkGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Renal-Electrolyte Section Philadelphia VA Hospital University of Pennsylvania School of Medicine Philadelphia, PA 19104 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTherapeutic Advances in Hyponatremia: Fluids, Diuretics, Vaptans, and MoreHyponatremia and HypernatremiaAn adenylate cyclase inhibitor in the treatment of excited psychosisThe Pharmacologic Management of the Syndrome of Inappropriate Secretion of Antidiuretic HormoneDemeclocycline-Induced Natriuresis and Renal Insufficiency: In Vivo and In Vitro StudiesClinical implications of research on the mechanism of action of lithiumTetracycline NephrotoxicityDemeclocycline therapy for resistant oedema in advanced cardiac failureHypopituitarism with water intoxication and coma: favorable outcome following early treatmentAnnotation on hyponatremiaDemeclocycline in the treatment of the syndrome of inappropriate secretion of antidiuretic hormone.Effects of tetracyclines on aldosterone- and insulin-mediated Na+ transport in the toad urinary bladderDemeclocycline in the treatment of the syndrome of inappropriate antidiuretic hormone release: with measurement of plasma ADHSuperiority of Demeclocycline over Lithium in the Treatment of Chronic Syndrome of Inappropriate Secretion of Antidiuretic HormoneNew Treatments for HyponatremiaTherapie der hyponatriämischen Herzinsuffizienz mit Glukose-Insulin-Kalium-Infusionen und mit Demeclocyclin 1 January 1977Volume 86, Issue 1Page: 113-114KeywordsBlood plasmaCirrhosisDemeclocyclineDrugsHyponatremiaSaltsSodiumSyndrome of inappropriate antidiuretic hormone secretionUreaUrine ePublished: 1 December 2008 Issue Published: 1 January 1977 PDF downloadLoading ...