Population
Patients with Brugada syndrome and idiopathic ventricular fibrillation, 281 controls, and HEK Na1.5 stable…
Comparison
Genetic screening for MOG1 mutations and in… vs Healthy controls for genetic screening; control…
Design
Preclinical
Authors
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MOG1 variants merit screening consideration in BrS; leaves open clinical relevance pending larger validation studies.
MOG1 is identified as a new susceptibility gene for Brugada syndrome, where dominant-negative mutations impair Na(v)1.5 trafficking and reduce sodium current.
Kattygnarath et al. (2011) studied this question.
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