Population
Isolated rat atrial myocytes and neonatal rat cardiomyocytes transfected with Green Fluorescent…
Comparison
Methyl-beta-cyclodextrin application to deplete… vs Baseline state or MCD preloaded with cholesterol
Design
Preclinical
Authors
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Membrane cholesterol modulates Kv1.5 distribution and function in cardiomyocytes; extends mechanistic insights but leaves open any translational relevance to arrhythmias.
Depletion of membrane cholesterol redistributes Kv1.5 subunits and increases their current-carrying capacity in rat cardiomyocytes, highlighting the role of lipid microdomains in channel function.
Abi-Char et al. (2007) studied this question.
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