Why the study?
Although ANGPTL6 is an anti-obesity hepatokine, serum levels are elevated in metabolic diseases, prompting investigation into whether ANGPTL6 levels are associated with new-onset metabolic syndrome.
Do elevated baseline serum ANGPTL6 levels predict new-onset metabolic syndrome in adults without metabolic syndrome?
Do elevated baseline serum ANGPTL6 levels predict new-onset metabolic syndrome in adults without metabolic syndrome?
Increased baseline serum ANGPTL6 levels independently predict the development of new-onset metabolic syndrome, suggesting its potential utility as a biomarker for metabolic stress.
Answers are grounded in this paper and cite their sources.
Elevated ANGPTL6 may flag higher metabolic syndrome risk; leaves open its value as a biomarker beyond established predictors.
Background: Despite being an anti-obesity hepatokine, the levels of serum angiopoietin-like 6 (ANGPTL6) are elevated in various metabolic diseases. Thus, ANGPTL6 expression may reflect metabolic burden and may have compensatory roles. This study investigated the association between serum ANGPTL6 levels and new-onset metabolic syndrome. Methods: In total, 221 participants without metabolic syndrome were randomly selected from a rural cohort in Korea. Baseline serum ANGPTL6 levels were measured using an enzyme-linked immunosorbent assay. Anthropometric and biochemical markers were analyzed before and after follow-up examinations. Results: During an average follow-up period of 2.75 (interquartile range, 0.76) years, 82 participants (37.1%) presented new-onset metabolic syndrome and had higher ANGPTL6 levels before onset than those without metabolic syndrome (48.0318.84 ng/mL vs. 64.7543.35 ng/mL, P=0.001). In the multivariable adjusted models, the odds ratio for the development of metabolic syndrome in the highest quartile of ANGPTL6 levels was 3.61 (95% confidence interval, 1.27 to 10.26). The use of ANGPTL6 levels in addition to the conventional components improved the prediction of new-onset metabolic syndrome (area under the receiver operating characteristic curve: 0.775 vs. 0.807, P=0.036). Conclusion: Increased serum ANGPTL6 levels precede the development of metabolic syndrome and its components, including low high density lipoprotein, high triglyceride, and high glucose levels, which have an independent predictive value for metabolic syndrome.
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Namkung et al. (2019) studied this question.
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