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March 14, 2018PLoS ONEOpen Access

Association of circulating ANGPTL 3, 4, and 8 levels with medical status in a population undergoing routine medical checkups: A cross-sectional study

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Population

988 Japanese subjects undergoing routine health checks in fasting conditions, median age 49, 53.6% male.

Design

Cross-sectional

Authors

JMJun MorinagaKumamoto University HospitalJZJiabin ZhaoHarbin Medical UniversityMEMotoyoshi EndoUniversity of Occupational and Environmental Health Japan

Discussion

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Overview

May inform ANGPTL-targeted therapy research; leaves open causal roles in cardiovascular risk.

Key Points

  • This study aims to explore the association between circulating ANGPTL 3, 4, and 8 levels and cardiovascular disease risk.
  • Conducted a single center, cross-sectional study of 988 Japanese subjects
  • Measured serum ANGPTL3, 4, and 8 levels using enzyme-linked immunosorbent assay
  • Employed multiple regression analysis to assess associations with medical status and risk factors.
  • High circulating ANGPTL3 levels were associated with hepatic impairment and inflammation.
  • ANGPTL4 levels were significantly elevated in subjects with impaired glycometabolism or hepatic impairment, but decreased in inflammation.
  • ANGPTL8 levels increased with obesity, impaired glycometabolism, and dyslipidemia, positively correlating with triglycerides and LDL-cholesterol, and inversely with HDL-cholesterol.

Structured PICO

P
Population
988 Japanese subjects undergoing routine health checks in fasting conditions, median age 49, 53.6% male.
O
Outcome
Association of circulating ANGPTL3, 4, and 8 levels with general medical status (including age, sex, smoking, drinking, obesity, hypertension, impaired glycometabolism, dyslipidemia, hyperuricemia, hepatic impairment, chronic kidney disease, anemia, cardiac abnormality, and inflammation)surrogate

Circulating levels of ANGPTL3, 4, and 8 are differentially associated with specific cardiovascular risk factors, with ANGPTL8 particularly linked to obesity and dyslipidemia.

Limitations

  • The ELISA assay used detects only the full-length form of ANGPTL3, which may not be associated with altered TG levels
  • Further analysis is necessary to determine which form of ANGPTL3 is associated with altered circulating cholesterol levels

Cite This Study

Morinaga et al. (2018) studied this question.

synapsesocial.com/papers/6a0510e2fba2ba61ab55fa1fhttps://doi.org/10.1371/journal.pone.0193731
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1ANGPTL3 Stimulates Endothelial Cell Adhesion and Migration via Integrin αvβ3 and Induces Blood Vessel Formation in Vivo2002 · 256 citations
  2. 2Increased ANGPTL3, 4 and ANGPTL8/betatrophin expression levels in obesity and T2D2016 · 106 citations
  3. 3Quantitation of serum angiopoietin-like proteins 3 and 4 in a Finnish population sample2009 · 108 citations
  4. 4Circulating ANGPTL8/Betatrophin Is Increased in Obesity and Reduced after Exercise Training2016 · 95 citations
  5. 5The angiopoietin-like protein 32013 · 37 citations