September 7, 2021Frontiers in Public HealthOpen Access

Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study

Q: What is the clinical evidence from this study?

Study design: Case-Control. Population: Renal dysfunction (n=270). Intervention: Elevated circulating ANGPTL8 levels vs. Lowest quartile of ANGPTL8 levels. Primary outcome: Renal dysfunction (eGFR < 60 ml/min/1.73 m2) (OR 3.80, 95% CI 1.71-8.41).

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Key result

Elevated circulating ANGPTL8 levels were associated with a significantly increased risk of renal dysfunction (OR 3.80 for highest vs lowest quartile) in Chinese adults.

Why the study?

Serum ANGPTL8 is increased in diabetes with albuminuria, but its association with kidney function in the general population was unestablished.

Population

135 matched case-control pairs from the REACTION study

Comparison

Renal dysfunction (eGFR <60/min/1.73 m 2) vs controls (eGFR ≥ 90 ml/min/1.73 m 2)

Design

Matched case-control study

Authors

XMXiaoyu MengChina University of Petroleum, Beijing HZHuajie ZouQinghai University Affiliated Hospital DLDanpei LiHuazhong University of Science and Technology

Discussion

Member takes

Overview

Elevated ANGPTL8 was associated with renal dysfunction risk; leaves open its value as biomarker or target pending prospective validation.

Study Design

Type

Case-Control (n=270)

Multicenter

Yes

Structured PICO

Population

270 adults aged 40 years and older, consisting of 135 patients with renal dysfunction and 135 matched controls with normal renal function from China.

Comparator

Control group with normal renal function (eGFR ≥ 90 ml/min/1.73 m2)

Outcome

Renal dysfunction (defined as eGFR < 60 ml/min/1.73 m2)surrogate

Main Result

Odds Ratio: 3.8 (95% CI 1.71–8.41)

Elevated circulating ANGPTL8 levels are independently associated with an increased risk of renal dysfunction in the general population.

Limitations

All participants were Chinese, limiting the generalizability of the findings to other ethnic groups.
The cross-sectional study design limits the interpretation of a causal relationship between ANGPTL8 levels and renal dysfunction.
The sample size of the study was relatively small.
All participants were Chinese, limiting generalizability to other ethnic groups
Cross-sectional study design limits interpretation of causal relationships
Relatively small sample size

Cite This Study

Meng et al. (2021) conducted a case-control in Renal dysfunction (n=270). Elevated circulating ANGPTL8 levels vs. Lowest quartile of ANGPTL8 levels was evaluated on Renal dysfunction (eGFR < 60 ml/min/1.73 m2) (OR 3.80, 95% CI 1.71-8.41). Elevated circulating ANGPTL8 levels were associated with a significantly increased risk of renal dysfunction (OR 3.80 for highest vs lowest quartile) in Chinese adults.

synapsesocial.com/papers/6a748b68b1c5cc4eb2b1bf95 https://doi.org/10.3389/fpubh.2021.710504

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September 7, 2021Frontiers in Public HealthOpen Access

Association of Circulating ANGPTL8 Levels With Renal Dysfunction: A Case-Control Study

View Full Paper

Ask AI

Bookmark

Key result

Elevated circulating ANGPTL8 levels were associated with a significantly increased risk of renal dysfunction (OR 3.80 for highest vs lowest quartile) in Chinese adults.

Why the study?

Serum ANGPTL8 is increased in diabetes with albuminuria, but its association with kidney function in the general population was unestablished.

Population

135 matched case-control pairs from the REACTION study

Comparison

Renal dysfunction (eGFR <60/min/1.73 m 2) vs controls (eGFR ≥ 90 ml/min/1.73 m 2)

Design

Matched case-control study

Authors

XMXiaoyu MengChina University of Petroleum, Beijing HZHuajie ZouQinghai University Affiliated Hospital DLDanpei LiHuazhong University of Science and Technology

Discussion

Member takes

Overview

Elevated ANGPTL8 was associated with renal dysfunction risk; leaves open its value as biomarker or target pending prospective validation.

Study Design

Type

Case-Control (n=270)

Multicenter

Yes

Structured PICO

Population

270 adults aged 40 years and older, consisting of 135 patients with renal dysfunction and 135 matched controls with normal renal function from China.

Comparator

Control group with normal renal function (eGFR ≥ 90 ml/min/1.73 m2)

Outcome

Renal dysfunction (defined as eGFR < 60 ml/min/1.73 m2)surrogate

Main Result

Odds Ratio: 3.8 (95% CI 1.71–8.41)

Elevated circulating ANGPTL8 levels are independently associated with an increased risk of renal dysfunction in the general population.

Limitations

All participants were Chinese, limiting the generalizability of the findings to other ethnic groups.
The cross-sectional study design limits the interpretation of a causal relationship between ANGPTL8 levels and renal dysfunction.
The sample size of the study was relatively small.
All participants were Chinese, limiting generalizability to other ethnic groups
Cross-sectional study design limits interpretation of causal relationships
Relatively small sample size

Cite This Study

synapsesocial.com/papers/6a748b68b1c5cc4eb2b1bf95 https://doi.org/10.3389/fpubh.2021.710504

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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