Key result
Elevated serum ANGPTL8 levels were significantly associated with increased odds of macroalbuminuria (OR 4.89) in patients with type 2 diabetes.
Why the study?
Are elevated serum ANGPTL8 levels associated with increased odds of albuminuria in patients with type 2 diabetes?
Cross-Sectional (n=228)
No
Are elevated serum ANGPTL8 levels associated with increased odds of albuminuria in patients with type 2 diabetes?
Odds Ratio: 4.89 (95% CI 2.1–11.39)
p-value: p=<0.001
Elevated serum ANGPTL8 levels are independently associated with micro- and macroalbuminuria in patients with type 2 diabetes, suggesting its potential as a biomarker for diabetic kidney disease.
ANGPTL8-albuminuria association in type 2 diabetes is hypothesis-generating; leaves open biomarker or therapeutic role pending prospective validation.
Background: Hyperglycemia, insulin resistance and hypertriglyceridesmia are risk factors for albuminuria in type 2 diabetes. Angiopoietin-like Protein 8(ANGPTL8) is a newly identified liver-derived hormone related to these risk factors. Hence, we aimed to explore the relationship between ANGPTL8 and albuminuria in type 2 diabetes. Methods: Serum ANGPTL8 levels were determined in groups of control (n = 50) and type 2 diabetic patients with normoalbuminuria (A1, n = 100), microalbuminuria (A2, n = 45), and macroalbuminuria (A3, n = 33). Results: Serum levels of ANGPTL8 and triglycerides were significantly increased in type 2 diabetic patients with albuminuria as compared with controls (P < 0.001). ANGPTL8 levels were positively correlated with triglycerides, duration of diabetes, and urine albumin-to-creatinine ratio (ACR) and negatively correlated with estimated glomerular filtration rate in type 2 diabetic patients with A2 and A3 (all P < 0.05). Logistic regression analysis indicated that ANGPTL8 had higher odds of having A2 (OR= 2.52, 95 % CI 1.16–5.48, P = 0.019) and A3 (OR = 4.89, 95 % CI 2.10–11.39, P<0.001) in type 2 diabetes. Mediation analysis indicated that triglycerides might act as a partial mediator in the relationship between ANGPTL8 and ACR. Conclusions: Triglycerides might partially mediate the correlation between ANGPTL8 and ACR. Our data provide the evidence for a strong link between ANGPTL8 and albuminuria, indicating that ANGPTL8 may be a new biomarker for diabetic kidney disease in type 2 diabetes.
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Yang et al. (2018) conducted a cross-sectional in Type 2 diabetes with albuminuria (n=228). Serum ANGPTL8 vs. Lower ANGPTL8 levels was evaluated on Macroalbuminuria (A3) in type 2 diabetes (OR 4.89, 95% CI 2.10-11.39, p=<0.001). Elevated serum ANGPTL8 levels were significantly associated with increased odds of macroalbuminuria (OR 4.89) in patients with type 2 diabetes.
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