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October 17, 2014The Journal of Clinical Endocrinology & MetabolismOpen Access

Circulating Angiopoietin-like Protein 8 Is Independently Associated With Fasting Plasma Glucose and Type 2 Diabetes Mellitus

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Population

120 subjects, with about half in each group on chronic hemodialysis or having eGFR >50 mL/min/1.73 m2. Also…

Design

Cross-sectional

Authors

TEThomas EbertUniversity Hospital LeipzigSKS KralischLeipzig UniversityAHAnnett HoffmannGoethe University Frankfurt

Discussion

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Implication

Angptl8 independently associates with T2DM; hypothesis-generating for causality, should not yet change practice.

Structured PICO

P
Population
120 subjects (62 patients with T2DM and 58 nondiabetic subjects), with about half in each group on chronic hemodialysis or having eGFR >50 mL/min/1.73 m2. Also included in vitro 3T3-L1 adipocytes.
C
Comparator
Nondiabetic subjects
O
Outcome
Serum Angptl8 levelssurrogate

Circulating Angptl8 is independently associated with T2DM and fasting glucose, suggesting a role in human glucose metabolism.

Cite This Study

Ebert et al. (2014) studied this question.

synapsesocial.com/papers/6a87b10de6314279fbfb0589https://doi.org/10.1210/jc.2013-4349
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