What is the clinical evidence from this study?

Study design: Case-Control. Population: Type 2 Diabetes Mellitus (n=90). Intervention: Type 2 Diabetes Mellitus vs. Healthy controls. Primary outcome: Serum ANGPTL8 level (pg/dl) (p=<0.0001).

August 15, 2022International Journal of Health SciencesOpen Access

The predictive diagnosis for ANGPTL8 level in women with T2DM

Q: What are the key findings of this study?

Serum ANGPTL8 levels were significantly elevated in women with type 2 diabetes compared to healthy controls (4432.89 vs 2892.11 pg/dl, p<0.0001) and correlated negatively with total cholesterol and LDL.

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Key result

Serum ANGPTL8 levels were significantly elevated in women with type 2 diabetes compared to healthy controls (4432.89 vs 2892.11 pg/dl, p<0.0001) and correlated negatively with total cholesterol and LDL.

Comparison

Patients with type 2 diabetes mellitus vs healthy age- and sex-matched controls

Authors

AFAws Safaa Fadhel MAManal F. Al-KhakaniUniversity of Kufa

Discussion

Member takes

Overview

May support ANGPTL8 as T2DM biomarker in women; hypothesis-generating and requires prospective validation before clinical use.

Study Design

Type

Case-Control (n=90)

Multicenter

Structured PICO

Population

90 Iraqi women, comprising 60 with type 2 diabetes mellitus and 30 healthy controls, were evaluated to assess the association between serum ANGPTL8 levels and metabolic markers.

Comparator

30 healthy age- and sex-matched women

Outcome

Serum ANGPTL8 levelssurrogate

Main Result

Absolute Event Rate: 4432.89% vs 2892.11%

p-value: p=<0.0001

Elevated serum ANGPTL8 levels are significantly associated with type 2 diabetes mellitus, insulin resistance, and dyslipidemia in women, suggesting its potential role as a biomarker for T2DM.

Limitations

Modest sample size
Lack of mechanistic basis to confirm findings
Potential confounding by other parameters like total cholesterol and triglycerides
Cross-sectional design limits causal inference regarding obesity and ANGPTL8 progression
Modest sample size, especially in the T2DM group
The link between ANGPTL8 level and HbA1c could be due to multiple parameters (e.g., TC and TG levels)
Not the first study to reveal ANGPTL8's role in T2DM progression

Cite This Study

Fadhel et al. (2022) conducted a case-control in Type 2 Diabetes Mellitus (n=90). Type 2 Diabetes Mellitus vs. Healthy controls was evaluated on Serum ANGPTL8 level (pg/dl) (p=<0.0001). Serum ANGPTL8 levels were significantly elevated in women with type 2 diabetes compared to healthy controls (4432.89 vs 2892.11 pg/dl, p<0.0001) and correlated negatively with total cholesterol and LDL.

synapsesocial.com/papers/6a987331e1a021e57bd4b223 https://doi.org/10.53730/ijhs.v6ns4.11784

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August 15, 2022International Journal of Health SciencesOpen Access

The predictive diagnosis for ANGPTL8 level in women with T2DM

View Full Paper

Ask AI

Bookmark

Key result

Comparison

Patients with type 2 diabetes mellitus vs healthy age- and sex-matched controls

Authors

AFAws Safaa Fadhel MAManal F. Al-KhakaniUniversity of Kufa

Discussion

Member takes

Overview

May support ANGPTL8 as T2DM biomarker in women; hypothesis-generating and requires prospective validation before clinical use.

Study Design

Type

Case-Control (n=90)

Multicenter

Structured PICO

Population

90 Iraqi women, comprising 60 with type 2 diabetes mellitus and 30 healthy controls, were evaluated to assess the association between serum ANGPTL8 levels and metabolic markers.

Comparator

30 healthy age- and sex-matched women

Outcome

Serum ANGPTL8 levelssurrogate

Main Result

Absolute Event Rate: 4432.89% vs 2892.11%

p-value: p=<0.0001

Elevated serum ANGPTL8 levels are significantly associated with type 2 diabetes mellitus, insulin resistance, and dyslipidemia in women, suggesting its potential role as a biomarker for T2DM.

Limitations

Modest sample size
Lack of mechanistic basis to confirm findings
Potential confounding by other parameters like total cholesterol and triglycerides
Cross-sectional design limits causal inference regarding obesity and ANGPTL8 progression
Modest sample size, especially in the T2DM group
The link between ANGPTL8 level and HbA1c could be due to multiple parameters (e.g., TC and TG levels)
Not the first study to reveal ANGPTL8's role in T2DM progression

Cite This Study

synapsesocial.com/papers/6a987331e1a021e57bd4b223 https://doi.org/10.53730/ijhs.v6ns4.11784

Also Consider

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