Key result
ANGPTL-8 plays a complex and controversial role in type 2 diabetes and lipid metabolism, with conflicting evidence regarding its association with insulin resistance and glucose homeostasis.
Why the study?
The accurate function of ANGPTL-8 in type-2 diabetes remains unclear due to conflicting results across studies regarding its role in glucose metabolism and diabetes complications.
ANGPTL-8 is a novel hormone implicated in glucose and lipid metabolism, but its exact role in type 2 diabetes and insulin resistance remains controversial and requires further standardized studies.
ANGPTL-8 role in T2D remains unresolved; leaves open need for standardized studies before any clinical consideration.
ANGPTL8, a new hormone, is regarded as a novel target for type-2 diabetes and associated metabolic disorder. Nutritional state and hormonal factors are involved in the regulation of ANGPTL-8 expression. This protein is associated with some myokines or adipokines. Several studies confirmed the function of ANGPTL-8 in glucose metabolism and diabetes complications; however, there are opposite results. The accurate function of ANGPTL-8 in T2D remains unclear. Further strictly controlled studies including measuring methods, nutritional state, diagnostic criteria of overweight/obesity, age, and ethnicity may help to resolve discrepancies. In addition, more studies are demanded to clarify the potential role of ANGPTL-8 in humans, a cause or an effect of this protein in association with insulin resistance, the regulatory mechanism of ANGPTL-8 expression, and the association of ANGPTL8 with other adipokines or myokines. In this mini review, we described various roles of ANGPTL-8 in diabetes.
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Esfahani et al. (2019) conducted a review in Type 2 diabetes and associated metabolic disorders. ANGPTL-8 was evaluated. ANGPTL-8 plays a complex and controversial role in type 2 diabetes and lipid metabolism, with conflicting evidence regarding its association with insulin resistance and glucose homeostasis.
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