What question did this study set out to answer?

The study aimed to evaluate the protective effects of Vernonia amygdalina against oxidative damage induced by 1-Nitropyrene in rats.

February 5, 2026Avicenna Journal of Medical BiochemistryOpen Access

Protective Effects of Vernonia amygdalina Extract Against 1-Nitropyrene-Induced Hepatopulmonary Oxidative Injury in Rats

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Authors

OIOmorede Ikponmwosa-EwekaUniversity of Science and Technology of Benin IMIkenna C. MaduakoBenson Idahosa University

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Implication

This experimental study shows that Vernonia amygdalina extract alleviates 1-NP-induced oxidative injury in rats, indicating its potential protective role.

Key Points

The study aimed to evaluate the protective effects of Vernonia amygdalina against oxidative damage induced by 1-Nitropyrene in rats.
Divided 35 rats into five groups and treated them with 1-NP alone or in combination with VA.
Administered treatments for 7 consecutive days via oral delivery.
Biochemically assessed levels of antioxidants and inflammatory markers post-treatment.
VA significantly improved antioxidant enzyme activities.
Decreased levels of proinflammatory markers RANTES, TNF-α, and IL-1β were observed.
VA mitigated 1-NP-induced oxidative stress and damage in hepatopulmonary tissues.

Cite This Study

Ikponmwosa-Eweka et al. (2025) studied this question.

synapsesocial.com/papers/69843583f1d9ada3c1fb451a https://doi.org/10.34172/ajmb.2630

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Implication

This experimental study shows that Vernonia amygdalina extract alleviates 1-NP-induced oxidative injury in rats, indicating its potential protective role.

Protective Effects of Vernonia amygdalina Extract Against 1-Nitropyrene-Induced Hepatopulmonary Oxidative Injury in Rats

Discussion

Member takes

Implication

Key Points

Cite This Study

Protective Effects of Vernonia amygdalina Extract Against 1-Nitropyrene-Induced Hepatopulmonary Oxidative Injury in Rats

Discussion

Member takes

Implication

Key Points

Cite This Study

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