Key result
ANGPTL8 is a crucial regulator of lipid metabolism, particularly triglyceride trafficking, and its circulating levels are altered in various metabolic disorders including diabetes and obesity.
ANGPTL8 plays a crucial role in lipid metabolism and triglyceride regulation, making it a potential therapeutic target for metabolic disorders, though it does not influence beta-cell proliferation as previously thought.
Suggests ANGPTL8 as a lipid target in metabolic disease; challenges prior beta-cell hypotheses and leaves therapeutic translation open.
Long-term controversy regarding the role of angiopoietin-like protein 8 (ANGPTL8) in beta-cell proliferation and diabetes progression made it a research spotlight. Recently, the controversy was resolved. Although ANGPTL8 could not control beta-cell expansion and islet function, ANGPTL8 was still considered as a novel but atypical member in the ANGPTL family because of its unique structure and crucial effects on lipid metabolism. Besides, ANGPTL8 also participated in some other disorders such as non-alcoholic fatty liver disease and renal dysfunction. Understanding the features of ANGPTL8 may offer new diagnostic and therapeutic approaches to metabolic-related diseases. Therefore, we reviewed most recent findings about ANGPTL8 and aimed to provide an integrated picture of ANGPTL8.
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Luo et al. (2018) conducted a review in Metabolic Disorders. ANGPTL8 was evaluated. ANGPTL8 is a crucial regulator of lipid metabolism, particularly triglyceride trafficking, and its circulating levels are altered in various metabolic disorders including diabetes and obesity.
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