Key result
Women with type 2 diabetes mellitus had higher serum ANGPTL8 levels compared to healthy controls, suggesting its potential role as a biochemical marker.
Case-Control (n=90)
No
Serum ANGPTL8 levels are significantly elevated in women with type 2 diabetes and correlate with markers of insulin resistance and dyslipidemia, suggesting its potential as a biochemical marker for the disease.
Answers are grounded in this paper and cite their sources.
No immediate clinical role for ANGPTL8 in T2DM; hypothesis-generating for biomarker utility in larger prospective studies.
Background: The metabolic syndrome including type 2 diabetes mellitus(T2DM), insulin resistance(IR), obese, hypertension, and dyslipidemia, is an increasing health burden. In the last decade, various metabolic hormones have been noticed to significantly role obese and associated complications. for example of this, the adipokines or hepatokines secreted proteins from hepatocyte and adipocyteare correlate with metabolic syndrome. Angiopoietin-like protein 8 (ANGPTL8) has a novel hepatokine or adipokine, which is mostly expressed in the adipose tissue, and liver stimulates the -cell proliferation as a pancreatic in an insulin resistance state. It's a recently discovered the endocrine regulator associated with glucose homeostasis, IR, and metabolism of lipid.
No takes yet. Share an insight, caveat, or question.
A 2022 study conducted a case-control in Type 2 Diabetes Mellitus (n=90). Type 2 Diabetes Mellitus vs. Healthy controls was evaluated on Serum ANGPTL8 levels (p=<0.0001). Women with type 2 diabetes mellitus had higher serum ANGPTL8 levels compared to healthy controls, suggesting its potential role as a biochemical marker.
Synapse has enriched 10 related papers. Consider them for comparative context: