What does this research mean for the field?

Helicobacter pylori infection in symptomatic children and adolescents without peptic ulcer disease is associated with profound gastric dysbiosis and severe histological gastritis, challenging current guidelines that advise against early eradication. Novelty: ClaimNovelty.CONTRADICTORY. Consensus alignment: ConsensusAlignment.CHALLENGES_CONSENSUS.

What question did this study set out to answer?

To determine the impact of Helicobacter pylori infection on gastric microbiota composition and histological gastritis severity in symptomatic pediatric patients without peptic ulcer disease.

August 31, 2026Frontiers in MicrobiologyOpen Access

Gastric dysbiosis and more severe histological gastritis in symptomatic Helicobacter pylori-infected children and adolescents without ulcers: time to rethink early eradication?

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Authors

DIDinka IvulicInstituto de Neurociencia Biomédica CCCamila CabreraSharp Mary Birch Hospital for Women & Newborns FCFelipe Del CantoInstituto de Neurociencia Biomédica

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Implication

Prospective multicenter study reveals gastric dysbiosis and severe gastritis in non-ulcerated Helicobacter pylori-infected youths, suggesting potential need for earlier eradication.

Key Points

To determine the impact of Helicobacter pylori infection on gastric microbiota composition and histological gastritis severity in symptomatic pediatric patients without peptic ulcer disease.
Prospective, multicenter study of 120 symptomatic patients aged 8–20 years undergoing endoscopy (41 H. pylori-positive and 79 H. pylori-negative).
Characterized gastric mucosal microbiota profiles using 16S rRNA gene sequencing.
Evaluated histological gastritis severity scores and detected H. pylori CagA virulence factor status.
H. pylori-positive patients showed significant microbial diversity reduction, higher dominance index, and distinct beta diversity clustering versus uninfected individuals (p < 0.001), with decreased Firmicutes and Bacteroidota.
Microbiota alterations and co-occurrence of H. pylori with three marker species correlated with more severe histological gastritis, showing no variation by age, sex, or pubertal stage.
Presence of the CagA virulence factor was associated with altered microbiota composition but did not correlate with histological gastritis severity.

Cite This Study

Ivulic et al. (2026) studied this question.

synapsesocial.com/papers/6a9541eaf20e493292a741fa https://doi.org/10.3389/fmicb.2026.1927606

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Implication

Prospective multicenter study reveals gastric dysbiosis and severe gastritis in non-ulcerated Helicobacter pylori-infected youths, suggesting potential need for earlier eradication.

Gastric dysbiosis and more severe histological gastritis in symptomatic Helicobacter pylori-infected children and adolescents without ulcers: time to rethink early eradication?

Discussion

Member takes

Implication

Key Points

Cite This Study

Gastric dysbiosis and more severe histological gastritis in symptomatic Helicobacter pylori-infected children and adolescents without ulcers: time to rethink early eradication?

Discussion

Member takes

Implication

Key Points

Cite This Study

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