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Theoretical analysis reveals recursive multisystem timing incoherence in Parkinson's disease, suggesting that locked neural frequencies perpetuate durable disease states.
Is Parkinson's disease a localized brain disorder, or a distributed, self-maintaining topological state? This monograph leverages the Terrain–Timing framework to model Parkinson's disease as a recursive, multi-terrain timing incoherence. It illustrates how gut microbial, metabolic, and neuro-electrophysiological layers alter one another reciprocally until a downstream consequence becomes an upstream driver. It formalizes the loss of neural metastability as a "Frequency Trap" (characterized by hyper-stabilized beta-band oscillations) and introduces the Chain-Link Principle to differentiate simple temporal displacement from durable, structural disease reconfigurations.
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Jacqueline J. Horsford (2026) studied this question.
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