Key result
Polymerase chain reaction (PCR) successfully detected a monoclonal population at the DNA level in lymphoma cells from a 75-year-old man with primary cardiac lymphoma.
Case Report (n=1)
PCR can be effectively applied to detect monoclonality at the DNA level to aid in the diagnosis of primary cardiac lymphoma.
May aid primary cardiac lymphoma diagnosis; leaves open validation in larger cohorts.
A 75-year-old man initially complained of pollakiuria and low abdominal pain, and died of massive bleeding from an exacerbated gastric ulcer. The diagnosis of primary cardiac lymphoma was made postmortem. The tumor involved only the epicardium and myocardium, which met the criteria of primary cardiac lymphoma as defined by the Armed Forces Institute of Pathology. The lymphoma consisted of large cells and expressed the B cell marker, CD20. Although chronic inflammation due to chronic renal failure was observed in the pericardium around the lymphoma, polymerase chain reaction (PCR) was conducted to detect monoclonality at the DNA level in lymphoma cells, which were shown to comprise a monoclonal population.
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Kasai et al. (1992) conducted a case report in Primary cardiac lymphoma (n=1). Polymerase chain reaction (PCR) was evaluated on Detection of monoclonality at the DNA level in lymphoma cells. Polymerase chain reaction (PCR) successfully detected a monoclonal population at the DNA level in lymphoma cells from a 75-year-old man with primary cardiac lymphoma.
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