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February 1, 1990Clinical & Experimental ImmunologyOpen Access

M-PGE1 significantly ameliorated proteinuria at day 4 (61 +/- 13 mg/24 h vs vehicle 164 +/- 17 mg/24 h, P < 0.002) and reduced infiltrating macrophages (44 +/- 9 vs 119 +/- 15/glomerulus, P < 0.02).

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Why the study?

Does 15(s)-15-methyl PGE1 reduce proteinuria and macrophage infiltration in a rat model of accelerated nephrotoxic nephritis?

Population

Rats with accelerated nephrotoxic nephritis and normal rats

Comparison

15(s)-15-methyl PGE1 (M-PGE1) vs Vehicle

Design

Preclinical

Follow-up

4 days

Authors

VCVictoria CattellJSJennifer SmithHCH. Terence Cook

Discussion

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Overview

Supports macrophage suppression in experimental GN; leaves open translation to human glomerulonephritis.

Structured PICO

Does 15(s)-15-methyl PGE1 reduce proteinuria and macrophage infiltration in a rat model of accelerated nephrotoxic nephritis?

P
Population
Rats with accelerated nephrotoxic nephritis (a model of acute macrophage-dependent glomerular injury) and normal rats
I
Intervention
15(s)-15-methyl PGE1 (M-PGE1)
C
Comparator
Vehicle
O
Outcome
Proteinuria and glomerular hypercellularitysurrogate

Prostaglandin E1 suppresses macrophage accumulation and activation, ameliorating injury in a rat model of macrophage-dependent glomerulonephritis.

Cite This Study

Cattell et al. (1990) studied this question.

synapsesocial.com/papers/6a9544df3d7e4fca39b2dc08https://doi.org/10.1111/j.1365-2249.1990.tb05188.x
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Suppression by prostaglandin E1 of vascular permeability induced by vasoactive inflammatory mediators.1980 · 112 citations
  2. 2Fc dependence of macrophage accumulation and subsequent injury in experimental glomerulonephritis.1983 · 52 citations
  3. 3Suppression of immune complex vasculitis in rats by prostaglandin.1979 · 128 citations
  4. 4Suppression of acute and chronic inflammation in adrenalectomized rats by pharmacologic amounts of prostaglandins1973 · 96 citations