Key result
The native porcine aortic annulus exhibited asymmetric dynamics, with the highest force development at the left/right interleaflet triangle (2.87 ± 2.08 N) and a more oval configuration during systole.
Why the study?
With new aortic root and valve repair techniques emerging, a detailed understanding of aortic annulus and valve dynamics is needed for optimal results.
The native aortic annulus exhibits heterogeneous segmental dynamics and force distribution, suggesting that different segments may require tailored support during aortic root and valve repair.
PURPOSE: With new repair techniques of the aortic root and valve emerging, a detailed understanding of the dynamics of the aortic annulus and valve is required for optimal results. The objective of this study was to characterize geometrical changes and force distribution of the native porcine aortic annulus throughout the cardiac cycle. METHODS: Measurements were performed in an acute 80 kg porcine model (n = 7) using sonomicrometry crystals in the aortic annulus for evaluation of geometry and dynamics, annular force transducer evaluating force distribution, and pressure measurements and echocardiography evaluating valve performance. RESULTS: Overall, segmental force distribution and geometrical changes differed between different segments of the aortic annulus. The highest force development was found at the left/right interleaflet triangle (2.87 ± 2.1 N) and the largest segmental expansion was observed at the right-coronary and left-coronary sinus. The aortic annulus changed configuration throughout the cardiac cycle and became more oval in systole. CONCLUSIONS: This study is the first to describe detailed segmental dynamics and force distribution of the native aortic annulus in a porcine model in vivo. The heterogenous behavior of the aortic annulus suggests that different segments demand different support for repair of the aortic root and valve.
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Benhassen et al. (2019) studied Healthy (evaluation of native aortic annulus) (n=7). Force transducer and sonomicrometry evaluation was evaluated on Maximum-Minimum radial force at the left/right interleaflet triangle (p=<0.05). The native porcine aortic annulus exhibited asymmetric dynamics, with the highest force development at the left/right interleaflet triangle (2.87 ± 2.08 N) and a more oval configuration during systole.
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