The distribution of immunoreactive LHRH in the human ovary was examined using paraffin sections by peroxidase immunocytochemistry. Immunoreactive LHRH is seen in the granulosa cells of mature follicles, and in the theca interna cells of atretic follicles. But the immunoreactive LHRH is not found in the theca interna cells or stromal components of mature follicles, and in the granulosa cells or stromal components of atretic follicles. There may be a possibility that immunoreactive LHRH serves as a paracrine modulator in follicular maturation.
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Huang et al. (1986) studied this question.
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