Key result
High serum uric acid concentrations (>6.6 mg/dL) were associated with a more than twofold increased odds (OR 2.19) of an exaggerated systolic blood pressure response to maximal exercise in normotensive men.
Why the study?
Does high serum uric acid associate with an exaggerated systolic blood pressure response to exercise testing in healthy men with normotension?
Cross-Sectional (n=4,640)
No
Does high serum uric acid associate with an exaggerated systolic blood pressure response to exercise testing in healthy men with normotension?
High serum uric acid concentrations are independently associated with an exaggerated systolic blood pressure response to maximal exercise in normotensive men, suggesting a potential role in early cardiovascular risk.
Answers are grounded in this paper and cite their sources.
High uric acid associated with exaggerated exercise SBP response in normotensives; leaves open predictive value and need for prospective validation.
The authors investigated the hypothesis that high serum uric acid concentrations may be related to an exaggerated systolic blood pressure (SBP) response to maximal exercise testing in men with normotension, independent of potential confounding variables. In 4640 healthy men with normotension who underwent maximal treadmill exercise testing and fasting blood chemistry studies, including serum uric acid concentrations, an exaggerated SBP response, defined as SBP ≥ 210 mm Hg, was detected in 152 men (3.3%). After adjusting for potential confounders, participants in the highest quartile of serum uric acid (>6.6 mg/dL) had a higher odds ratio of demonstrating an exaggerated SBP to maximal exercise (odds ratio, 2.19; 95% confidence interval, 1.24-3.86) compared with participants in the lowest quartile of serum uric acid (<5.1 mg/dL). High serum uric acid concentrations are associated with an exaggerated SBP response to maximal exercise testing in men with normotension, independent of established coronary risk factors.
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Jae et al. (2018) conducted a cross-sectional in Normotension (n=4,640). High serum uric acid concentrations vs. Lowest quartile of serum uric acid (<5.1 mg/dL) was evaluated on Exaggerated systolic blood pressure response to maximal exercise (SBP ≥ 210 mm Hg) (OR 2.19, 95% CI 1.24-3.86). High serum uric acid concentrations (>6.6 mg/dL) were associated with a more than twofold increased odds (OR 2.19) of an exaggerated systolic blood pressure response to maximal exercise in normotensive men.
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