Why the study?
Primary cardiac tumors are extremely rare and their diagnosis is often delayed due to nonspecific clinical symptoms.
Case Report (n=1)
No
This case report demonstrates the aggressive nature of primary cardiac angiosarcoma and the necessity of a multidisciplinary approach combining surgery and systemic therapy for metastatic disease.
PCAS may present with exertional palpitations before metastases; leaves open evidence-based management strategies.
Primary cardiac tumors are extremely rare, with an incidence rate ranging from only 0.17% to 0.33%. Clinically, their diagnosis is often delayed due to nonspecific clinical symptoms. This paper reports a case of primary cardiac angiosarcoma (PCAS) pathologically confirmed via surgery, presenting with recurrent palpitations during exertion as the initial symptom. The patient subsequently developed bilateral lung and liver metastases and received chemotherapy. Through a comprehensive review of the literature, this report explores the diagnostic and therapeutic strategies for PCAS, with a focus on analyzing the mechanisms underlying the atypical disease course, the rationale for treatment decisions, and the key clinical insights.
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Yin et al. (2025) conducted a case report in Primary cardiac angiosarcoma (n=1). Surgical resection and chemotherapy was evaluated on Clinical response.
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