Delivery plan: Thrombin binding aptamer tethered to lipid-coated mesoporous silica nanoparticles (TBA A15–lipid–MSN, above arrow) were rationally designed to deliver docetaxel for combined tumor cell suppression. The dual function of the bioconjugates in the extracellular matrix and cytoplasm of HeLa cells was demonstrated. This hybrid system could be extended for combined anticancer treatment when PAR-1 is over-expressed.
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Gao et al. (2011) studied this question.
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