Rational Design of Oncocin Derivatives with Superior Protease Stabilities and Antibacterial Activities Based on the High‐Resolution Structure of the Oncocin‐DnaK Complex

Countering MDR pathogens: The proline-rich designer peptide oncocin is highly active against a number of antibiotic-resistant, Gram-negative pathogens. Here we deduce residues critical to its activity and the crystal structure of an oncocin–DnaK complex from a positional Ala scan. New lead compounds were highly resistant against serum and E. coli proteases.