Why the study?
Do strategies that elevate intra-gastric pH reduce aspirin-induced bleeding?
Do strategies that elevate intra-gastric pH reduce aspirin-induced bleeding?
Strategies that elevate intra-gastric pH are effective in reducing aspirin-induced gastric bleeding in a short-term model system.
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pH-elevating strategies may reduce aspirin-induced bleeding in models; leaves open need for clinical trials before practice change.
Prostaglandins protect the gastric mucosa in animals, but the evidence of an effect independent of pH changes in man is not overwhelming. Gastrointestinal bleeding because of non-steroidal anti-inflammatory drugs is a major clinical problem, which we have investigated in a model system measuring bleeding rates caused by short-term administration of aspirin. Of the various strategies tested, only those that elevated intra-gastric pH reduced aspirin-induced bleeding.
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Hawkey et al. (1986) studied this question.
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