Key result
This narrative review provides an overview of the clinical presentations, laboratory and electrodiagnostic characteristics, and management of nitrous oxide-induced peripheral neuropathy.
Why the study?
Despite increasing recreational abuse of nitrous oxide, there remains inadequate understanding of the potential adverse effects resulting from exposure to it.
This narrative review summarizes the clinical presentation, diagnosis, and management of nitrous oxide-induced peripheral neuropathy, an increasingly prevalent condition due to recreational misuse.
May aid clinician recognition of nitrous oxide neuropathy; leaves open the need for prospective trials on management.
Under standard conditions, nitrous oxide (N2O) manifests as a colorless, odorless gas with a mildly sweet taste. The compound finds applications in various fields, including its use as an aerosol propellants, an accelerant in motor racing, and an anesthetic in surgical procedures and dentistry. Unfortunately, the recreational misuse of N2O has become prevalent among young individuals due to its euphoric and hallucinogenic effects. Compounding this issue is the fact that nitrous oxide can be easily obtained from over-the-counter household items, facilitating its non-medical use. The global community has witnessed a surge in the recreational utilization of nitrous oxide gas in recent years. Despite the widespread non-medical abuse of N2O, there remains inadequate understanding of the potential adverse effects resulting from exposure to it. This paper provides an overview of management findings, laboratory and electrodiagnostic characteristics, as well as clinical presentations associated with neurological disorders induced by nitrous oxide usage.
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Zou et al. (2024) conducted a review in Nitrous oxide-induced peripheral neuropathy. Nitrous oxide was evaluated. This narrative review provides an overview of the clinical presentations, laboratory and electrodiagnostic characteristics, and management of nitrous oxide-induced peripheral neuropathy.
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