A nonracemic compound is synthesized and shown to assemble reversibly through hydrogen bonding to form a cyclic tetramer. The chiral arrangement of atoms in the individual pieces becomes amplified through self-assembly to yield multiple functional groups asymmetrically arranged within the cavity. The tetrameric capsule shows a special affinity for ketones and is able to discriminate between their enantiomers in solution.
No takes yet. Share an insight, caveat, or question.
Nuckolls et al. (1999) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: