Chiral Capsules. 1. Softballs with Asymmetric Surfaces Bind Camphor Derivatives

Self-assembling “softballs” are hollow pseudospherical dimers held together by hydrogen bonds in organic solvents. They encapsulate smaller molecules of suitable size and shape. Stereochemical aspects of these systems are explored through the encapsulation of camphor derivatives. Both symmetrical softballs and those rendered chiral by functional groups on the softball's surface are examined by 1 H NMR methods.