Why the study?
Does low-dose methotrexate improve cardiac remodeling and function in a rat model of postmyocarditis?
Population
Rat model of cardiac myosin-induced experimental autoimmune myocarditis
Comparison
Low-dose methotrexate (0.1 mg/kg/d for 30 days) vs Saline treatment
Design
Preclinical
Follow-up
30 days
Authors
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May warrant trials of methotrexate for postmyocarditis remodeling; hypothesis-generating in this rat model and should not change practice.
Does low-dose methotrexate improve cardiac remodeling and function in a rat model of postmyocarditis?
Low-dose methotrexate regulates inflammatory responses and improves cardiac function, potentially preventing postmyocarditis dilated cardiomyopathy in a rat model.
Zhang et al. (2009) studied this question.
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