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January 29, 2004Organic Process Research & Development

Development of a Scaleable Synthesis of a 3-Aminopyrazinone Acetamide Thrombin Inhibitor

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Authors

MAMichael S. AshwoodMerck & Co., Inc., Rahway, NJ, USA (United States)RARamon J. AlabasterICIan F. Cottrell

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Ashwood et al. (2004) studied this question.

synapsesocial.com/papers/6a954d7d6a42edee3f2ca75bhttps://doi.org/10.1021/op0341420
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Kilogram Scale Synthesis of the Pyrazinone Acetic Acid Core of an Orally Efficacious Thrombin Inhibitor2000 · 28 citations
  2. 2Synthesis of Alkenyl- and Aryldifluoroacetate Using a Copper Complex from Ethyl Bromodifluoroacetate.1999 · 49 citations
  3. 3Metabolism-Directed Optimization of 3-Aminopyrazinone Acetamide Thrombin Inhibitors. Development of an Orally Bioavailable Series Containing P1 and P3 Pyridines2003 · 121 citations