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May 1, 1994Acta Anaesthesiologica Scandinavica

Local analgesic and vascular effects of intradermal ropivacaine and bupivacaine in various concentrations with and without addition of adrenaline in man

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Authors

ICIngemar CederholmLinköping University BAB AkermanUppsala University HEHans EversUniversity of Helsinki

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Implication

Randomized double-blind trial reveals ropivacaine induces longer dermal analgesia and greater blanching than bupivacaine in healthy males, indicating inherent vasoconstrictive properties.

Key Points

To compare the duration of dermal analgesia and local cutaneous vascular effects of intradermal ropivacaine and bupivacaine across various concentrations, both with and without adrenaline.
Randomized, double-blind, two-series trial conducted in 10 healthy, non-smoking young male volunteers with at least 3 weeks between series.
Series I evaluated plain ropivacaine (0.25%, 0.5%, 0.75%, 1%) and bupivacaine (0.25%, 0.5%, 0.75%) alongside saline control; Series II tested identical concentrations supplemented with adrenaline 5 µg/mL (1:200,000).
Analgesia duration was monitored using pin-prick sensation testing, while local vascular responses were graded visually as nil, pink, or pale.
Plain ropivacaine produced significantly longer durations of dermal analgesia than plain bupivacaine across all concentrations tested.
Adding adrenaline significantly increased the duration of dermal analgesia for both local anaesthetics.
Local blanching occurred significantly more often with plain ropivacaine at all concentrations, whereas plain bupivacaine produced dose-dependent redness; adding adrenaline provoked initial redness followed by widespread blanching for both agents.

Cite This Study

Cederholm et al. (1994) studied this question.

synapsesocial.com/papers/6a954dec6a9a0c380125efc8 https://doi.org/10.1111/j.1399-6576.1994.tb03901.x

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May 1, 1994Acta Anaesthesiologica Scandinavica

Local analgesic and vascular effects of intradermal ropivacaine and bupivacaine in various concentrations with and without addition of adrenaline in man

View Full Paper

Ask AI

Bookmark

Authors

ICIngemar CederholmLinköping University BAB AkermanUppsala University HEHans EversUniversity of Helsinki

Discussion

Member takes

Implication

Randomized double-blind trial reveals ropivacaine induces longer dermal analgesia and greater blanching than bupivacaine in healthy males, indicating inherent vasoconstrictive properties.

Key Points

To compare the duration of dermal analgesia and local cutaneous vascular effects of intradermal ropivacaine and bupivacaine across various concentrations, both with and without adrenaline.
Randomized, double-blind, two-series trial conducted in 10 healthy, non-smoking young male volunteers with at least 3 weeks between series.
Series I evaluated plain ropivacaine (0.25%, 0.5%, 0.75%, 1%) and bupivacaine (0.25%, 0.5%, 0.75%) alongside saline control; Series II tested identical concentrations supplemented with adrenaline 5 µg/mL (1:200,000).
Analgesia duration was monitored using pin-prick sensation testing, while local vascular responses were graded visually as nil, pink, or pale.
Plain ropivacaine produced significantly longer durations of dermal analgesia than plain bupivacaine across all concentrations tested.
Adding adrenaline significantly increased the duration of dermal analgesia for both local anaesthetics.
Local blanching occurred significantly more often with plain ropivacaine at all concentrations, whereas plain bupivacaine produced dose-dependent redness; adding adrenaline provoked initial redness followed by widespread blanching for both agents.

Cite This Study

Cederholm et al. (1994) studied this question.

synapsesocial.com/papers/6a954dec6a9a0c380125efc8 https://doi.org/10.1111/j.1399-6576.1994.tb03901.x

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