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It was found that 3,4-dibromosulfolane reacted with amines to give the corresponding 3,4-diaminosulfolane or 4-amino-2-sulfolene derivatives. Also, it was established that N,N′-dibenzyl-cis-ureylenetetrahydrothiophene as a precursor of biotin was derived from cis-3,4-bis(benzylamino)sulfolane prepared by the above reaction.
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Kotake et al. (1976) studied this question.
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