Key result
Among patients hospitalized with severe acute respiratory illness in South Africa, 8.2% tested positive for enterovirus, with EV-D68 being the most prevalent serotype.
Observational (n=10,260)
Enterovirus D68 is a prevalent serotype among patients hospitalized with severe acute respiratory illness in South Africa, highlighting the need for ongoing monitoring.
EV-D68 prevalence in South African SARI cases supports surveillance; leaves open its contribution to disease burden.
BACKGROUND: Human enteroviruses (EV) have been associated with severe acute respiratory illness (SARI) in South Africa. OBJECTIVES: We aimed to describe the molecular epidemiology of EV serotypes among patients hospitalized with SARI during 2009-2011. PATIENTS/METHODS: Study samples from patients were tested for the presence of enterovirus using a polymerase chain reaction assay. RESULTS: 8.2% (842/10 260) of SARI cases tested positive for enterovirus; 16% (7/45) were species EV-A, 44% (20/45) EV-B, 18% (8/45) EV-C and 22% (10/45) EV-D. Seventeen different EV serotypes were identified within EV-A to EV-D, of which EV-D68 (22%; 10/45) and Echovirus 3 (11%; 5/45) were the most prevalent. CONCLUSIONS: EV-D68 should be monitored in South Africa to assess the emergence of highly pathogenic strains.
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Hellferscee et al. (2017) conducted an observational in Severe acute respiratory illness (SARI) (n=10,260). Enterovirus infection was evaluated on Enterovirus positivity. Among patients hospitalized with severe acute respiratory illness in South Africa, 8.2% tested positive for enterovirus, with EV-D68 being the most prevalent serotype.
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