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January 1, 1981The Journal of AntibioticsOpen Access

A genetic approach to the biosynthesis of the Rifamycin-chromophore in Nocardia mediterranei. IV. Identification of 3-amino-5-hydroxybenzoic acid as a direct precursor of the seven-carbon amino starter-unit.

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OGOreste GhisalbaNovartis (Switzerland)JNJ. NüeschNovartis (Switzerland)

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Ghisalba et al. (1981) studied this question.

synapsesocial.com/papers/6a954fc7cd304312aafa78e1https://doi.org/10.7164/antibiotics.34.64
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A genetic approach to the biosynthesis of the rifamycin-chromophore in Nocardia mediterranei. I. Isolation and characterization of a pentose-excreting auxotrophic mutant of Nocardia mediterranei with drastically reduced rifamycin production.1978 · 23 citations
  2. 2A genetic approach to the biosynthesis of the Rifamycin-chromophore in Nocardia mediterranei. III. Isolation and identification of an early aromatic ansamycin-precursor containing the seven-carbon amino starter-unit and three initial acetate/propionate-units of the ansa chain.1981 · 45 citations
  3. 3The fate of certain organic acids and amides in the rabbit. 12. Aminohydroxybenzoic acids1951 · 20 citations