On Coagulation and Fibrinolysis in Acute Renal Insufficiency

Factors of the coagulation and fibrinolytic systems have been studied in 18 patients with acute renal insufficiency, 13 with acute tubular necrosis and 5 with glomerulonephritis. In six cases there was more or less pronounced thrombocytopenia, but in none of the patients were there certain signs of disseminated intravascular coagulation. The general picture of the coagulation and fibrinolytic systems in acute uraemia found in the present investigation was characterised by prolonged Ivy bleeding time, increased content of factor VIII and fibrinogen, low fibrinolytic activity and increased value for inhibitors of plasminogen activation, largely the same changes as those found in chronic uraemia.