Key result
Myosin VI, a unique minus-end directed motor protein, plays essential roles in cell migration, membrane protrusion, and cancer cell dissemination by regulating actin dynamics and cell adhesion.
This review highlights the potential roles of myosin VI in the events leading to cell motility.
Myosin VI merits testing as an anti-metastasis target; leaves open clinical translation pending interventional validation.
There is now increasing evidence that myosin motor proteins, together with the dynamic actin filament machinery and associated adhesion proteins, play crucial roles in the events leading to motility at the leading edge of migrating cells. Myosins exist as a large superfamily of diverse ATP-dependent motors, and in the present review, we focus on the unique minus-end-directed myosin VI, briefly discussing its potential functions in cell motility.
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Chibalina et al. (2009) conducted a review in Cell motility and cancer dissemination. Myosin VI was evaluated. Myosin VI, a unique minus-end directed motor protein, plays essential roles in cell migration, membrane protrusion, and cancer cell dissemination by regulating actin dynamics and cell adhesion.
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