Why the study?
Does E-4031 reduce proliferation in neoplastic hematopoietic cells?
Population
Primary lymphocytes, leukemias, and hematopoietic cell lines
Design
Preclinical
Authors
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HERG blockade may curb leukemic cell growth; leaves open whether this yields viable human therapy.
Does E-4031 reduce proliferation in neoplastic hematopoietic cells?
Selective up-regulation of h-erg occurs in neoplastic hematopoietic cells, and blocking HERG channels reduces their proliferation, suggesting a potential therapeutic target.
Smith et al. (2002) studied this question.
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