What is the clinical evidence from this study?

Study design: Case Report. Population: Drug-refractory ventricular arrhythmias (n=4). Intervention: Pulsed Field Ablation (PFA). Primary outcome: Procedural safety, acute efficacy, and early follow-up outcomes.

What question did this study set out to answer?

To evaluate the procedural safety, acute efficacy, and short-term outcomes of focal pulsed field ablation using a contact-force sensing catheter for drug-refractory ventricular arrhythmias.

January 23, 2026Journal of Cardiovascular Development and DiseaseOpen Access

Pulsed Field Ablation for the Treatment of Ventricular Arrhythmias Using a Focal, Contact-Force Sensing Catheter: A Single-Center Case Series and Review

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Key result

Focal pulsed field ablation using a contact-force sensing catheter achieved acute procedural success without complications and suppressed arrhythmias in 4 patients with drug-refractory VA.

Why the study?

Conventional radiofrequency catheter ablation for ventricular arrhythmias carries a risk of collateral thermal injury, making the ventricular application of myocardial-selective pulsed field ablation an evolving frontier.

Does focal pulsed field ablation improve acute efficacy and safety in patients with drug-refractory ventricular arrhythmias?

Comparison

Centauri PFA system with a focal, contact-force sensing irrigated catheter

Design

Single-center case series

Authors

CMCristian MartignaniElectrophysiology GMGiulia MassaroAzienda USL di Bologna ASAlberto SpadottoElectrophysiology

Discussion

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Implication

PFA may support selective ventricular ablation; leaves open efficacy and safety in broader populations.

Key Points

To evaluate the procedural safety, acute efficacy, and short-term outcomes of focal pulsed field ablation using a contact-force sensing catheter for drug-refractory ventricular arrhythmias.
Conducted a single-center case series of N=4 consecutive patients with drug-refractory ventricular arrhythmias (two with premature ventricular complexes and two with ischemic cardiomyopathy and scar-related ventricular tachycardia).
Performed ablations with the Centauri pulsed field ablation system integrated with a focal, contact-force sensing irrigated catheter (Tacticath SE) guided by high-density electroanatomical mapping.
All ablations achieved 100% acute procedural success with no reported adverse events, including coronary spasm, atrioventricular block, or pericardial effusion.
Both premature ventricular complex cases achieved acute suppression, demonstrating a ≥95% reduction in arrhythmic burden at 9- and 12-month follow-up.
In both ventricular tachycardia cases, arrhythmogenic substrate modification rendered clinical tachycardia non-inducible, with zero sustained episodes detected on device interrogation over 9 months.

Study Design

Type

Case Report (n=4)

Multicenter

Structured PICO

Does focal pulsed field ablation improve acute efficacy and safety in patients with drug-refractory ventricular arrhythmias?

Population

4 patients with drug-refractory ventricular arrhythmias treated with focal pulsed field ablation and followed for 9 to 12 months.

Intervention

Pulsed Field Ablation (PFA) using the Centauri PFA system integrated with a focal, contact-force sensing irrigated catheter guided by high-density mapping

Outcome

Procedural safety, acute efficacy, and early follow-up outcomescomposite

Focal pulsed field ablation using a contact-force sensing catheter appears feasible, safe, and effective for treating drug-refractory ventricular arrhythmias in this initial small case series.

Limitations

Larger studies are required to definitively confirm safety margins near critical structures.
small sample size
larger studies required to definitively confirm safety margins near critical structures

Cite This Study

Martignani et al. (2026) conducted a case report in Drug-refractory ventricular arrhythmias (n=4). Pulsed Field Ablation (PFA) was evaluated on Procedural safety, acute efficacy, and early follow-up outcomes. Focal pulsed field ablation using a contact-force sensing catheter achieved acute procedural success without complications and suppressed arrhythmias in 4 patients with drug-refractory VA.

synapsesocial.com/papers/6a955416d33c5efb307d0384 https://doi.org/10.3390/jcdd13020059

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Pulsed Field Ablation for the Treatment of Ventricular Arrhythmias Using a Focal, Contact-Force Sensing Catheter: A Single-Center Case Series and Review

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

Pulsed Field Ablation for the Treatment of Ventricular Arrhythmias Using a Focal, Contact-Force Sensing Catheter: A Single-Center Case Series and Review

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Limitations

Cite This Study

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