Key result
A new 7-parameter algorithm for computing the nonstandard oxyhemoglobin equilibrium curve was developed, which is simpler to implement and computationally more efficient than previous algorithms.
A new 7-parameter algorithm provides a simpler and more computationally efficient method for calculating the nonstandard oxyhemoglobin equilibrium curve.
Offers efficient oxyhemoglobin modeling for research; leaves open clinical validation before practice adoption.
We have modified a model for the oxyhemoglobin equilibrium curve (OHEC) and developed an algorithm for which the nonstandard OHEC can be computed. The model requires 2 parameters and a scaling factor (Sm.) The model parameters are: P*, the oxygen partial pressure where the slope of the OHEC is at its maximum, and a rate parameter K. We estimated P* = 2.76 ± 0.04 SE kPa and K = 0.544 ±0.044 (SE) kPa−1 from ten previous literature reports for the human OHEC at standard conditions (T = 37°C, pH = 7.4, PCO2 = 5.33kPa and the molar concentration ratio [DPG7sol;Hb] = 0.9). We also determined how P* and K vary under nonstandard conditions by comparing the modified model with two previous nonstandard OHEC algorithms in the literature. These variations can be characterized by an additional 4 parameters. The dimensionless parameter product KP* was found to be relatively insensitive to deviations from standard conditions. We propose a new algorithm for the nonstandard OHEC which requires a total of 7 parameters, is simpler to implement and is computationally more efficient than other algorithms we investigated.
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Buerk et al. (1986) studied Oxyhemoglobin equilibrium curve modeling. New 7-parameter algorithm for the nonstandard oxyhemoglobin equilibrium curve vs. Previous nonstandard OHEC algorithms was evaluated on Computation of the nonstandard oxyhemoglobin equilibrium curve. A new 7-parameter algorithm for computing the nonstandard oxyhemoglobin equilibrium curve was developed, which is simpler to implement and computationally more efficient than previous algorithms.
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