Rheumatic Symptoms During Tuberculosis Therapy

Article1 November 1965Rheumatic Symptoms During Tuberculosis TherapyA Manifestation of Isoniazid Toxicity?ARMIN E. GOOD, M.D., ROBERT A. GREEN, M.D., CHRIS J. D. ZARAFONETIS, M.D., F.A.C.P.ARMIN E. GOOD, M.D.Search for more papers by this author, ROBERT A. GREEN, M.D.Search for more papers by this author, CHRIS J. D. ZARAFONETIS, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-63-5-800 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn 1961 McKusicK and Hsu (1) described a rheumatic syndrome marked particularly by shoulder-hand involvement, occurring in 15 tuberculosis patients who had received drug therapy. Our purpose is to report our experience with 7 similar patients, including operative findings in 2 cases, and to review the evidence that suggests that isoniazid may be the precipitating agent.CLINICAL DESCRIPTIONIn Table 1 the fully developed syndrome is summarized. Typically the patient complains of sudden onset of joint pain, tenderness, and stiffness, often presenting in the hands, especially in proximal interphalangeal joints. Early severe pain is also noted in one or both...References1. MCKUSICKHSU ABJM: Clinical and metabolic studies of the shoulder-hand syndrome in tuberculous patients (abstract), in Xth Congress of the International League against Rheumatism, vol. 2. Minerva Medica, Turin, 1961; Arthritis Rheum. 4: 426, 1961. Google Scholar2. CECILKAMMERER RLWH: Rheumatoid arthritis in the aged. Amer. J. Med. 10: 439, 1951. CrossrefMedlineGoogle Scholar3. ZINGALEMINZERROSENBERGLEE SBLBSL: Drug-induced lupus-like syndrome. 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Author, Article, and Disclosure InformationAffiliations: Ann Arbor, MichiganFrom the Medical Service, Veterans Administration Hospital (The Rackham Arthritis Research Unit and The Simpson Memorial Institute), and the Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Mich.Requests for reprints should be addressed to Armin E. Good, M.D., Veterans Administration Hospital, 2215 Fuller Rd., Ann Arbor, Mich. 48105. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByL’épaule : une histoire de souplesseThe Stiff ShoulderDrug-Induced Rheumatic DisordersShoulder complaints in patients with reflex sympathetic dystrophy of the upper extremityTuberculosisPhenobarbital rheumatism in patients with brain tumorAlgodystrophy in pregnancy. Three case reportsSilica-Dust-Exposed Mine Workers with Scleroderma (systemic Sclerosis)SHOULDER-HAND SYNDROMEFasciitis and polyarthritis during antituberculous therapyOral and Gingival Changes in Systemic Sclerosis (Scleroderma)Clinical Pharmacology of Antitubercular DrugsFrozen shoulderPalmar Fasciitis and Polyarthritis Associated with Ovarian CarcinomaTHOMAS A. MEDSGER Jr., M.D., JONATHAN A. DIXON, M.D., VERNON F. GARWOOD, M.D.Development of a Scleroderma-like Illness during Therapy with L-5-Hydroxytryptophan and CarbidopaShoulder pain as a rheumatologic problemRheumatic disorders associated with diabetes mellitus: Literature reviewThe reflex sympathetic dystrophy syndromeHand deformities resembling rheumatoid arthritisIsoniazid HepatitisWILLIS C. MADDREY, M.D., JOHN K. BOITNOTT, M.D.Chemoprophylaxis of Tuberculosis: When Is the Benefit Worth the Risk and Cost?THOMAS MOULDING, M.D., F.A.C.P.Rheumatism and Chemotherapy of TuberculosisARMIN E. GOOD, M.D.Serum Transaminase Elevations and Other Hepatic Abnormalities in Patients Receiving IsoniazidLAWRENCE SCHARER, M.D., JAMES P. SMITH, M.D.A síndrome ombro-mão nas hemiplegias vascularesArthralgia in Pulmonary Tuberculosis during Chemotherapy 1 November 1965Volume 63, Issue 5Page: 800-807KeywordsArthralgiaDrug therapyHospital medicineIsoniazidMalnutritionMedical servicesPainRheumatic feverRheumatic painStiffness Issue Published: 1 November 1965 PDF DownloadLoading ...