Key result
Zn2+ blocked GABA-activated whole-cell currents in a non-competitive and voltage-independent way and reduced the probability of single-channel opening from 0.17 to 0.06.
Population
Rat cerebellar granule cells in culture
Comparison
GABA (0.5-300 microM) and Zn2+ (10-30 microM) vs Control condition (without Zn2+)
Design
Preclinical
Authors
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Zn2+ effects on cerebellar GABAA receptors are hypothesis-generating; leaves open relevance to human inhibitory signaling.
Zn2+ modulates GABA-activated currents in rat cerebellar granule cells by reducing the probability of channel opening, likely binding to an extracellular site on the GABAA receptor.
Kilic et al. (1993) studied this question. Zn2+ vs. Control condition was evaluated on Whole-cell and single-channel currents evoked by GABA. Zn2+ blocked GABA-activated whole-cell currents in a non-competitive and voltage-independent way and reduced the probability of single-channel opening from 0.17 to 0.06.
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