What question did this study set out to answer?

To describe the transition from primary hypothyroidism to hyperthyroidism and subsequent autoimmune diabetes in a patient with polyendocrine autoimmunity.

April 1, 1985European Journal of Endocrinology

Hyperthyroidism following primary hypothyroidism in association with polyendocrine autoimmunity

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Authors

PBP. M. BellWinnipeg Regional Health Authority DSD. G. SinnamonNorthern Health and Social Care Trust PSP. P. A. SmythUniversity of Essex

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Implication

Case report reveals the development of hyperthyroidism following primary hypothyroidism in a male patient, highlighting dynamic antibody shifts in polyendocrine autoimmunity.

Key Points

To describe the transition from primary hypothyroidism to hyperthyroidism and subsequent autoimmune diabetes in a patient with polyendocrine autoimmunity.
Evaluated a 37-year-old male with a history of primary hypothyroidism diagnosed 6 years prior presenting with hyperthyroidism symptoms and exophthalmos without goitre.
Performed 131I neck uptake following 7 days of triiodothyronine suppression, autoantibody profiling, thyroid growth-blocking immunoglobulin assays, and HLA genotyping.
Confirmed hyperthyroidism by non-suppression of 131I neck uptake after triiodothyronine, accompanied by thyroglobulin, thyroidal microsomal, and thyroid-stimulating immunoglobulins.
Identified HLA-B8, -B, -DR3, and -DR4 alleles alongside islet cell autoantibodies, which preceded the clinical onset of diabetes mellitus one year later.

Cite This Study

Bell et al. (1985) studied this question.

synapsesocial.com/papers/6a95555ca15fb1352cb2f0d8 https://doi.org/10.1530/acta.0.1080491

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Implication

Case report reveals the development of hyperthyroidism following primary hypothyroidism in a male patient, highlighting dynamic antibody shifts in polyendocrine autoimmunity.

Hyperthyroidism following primary hypothyroidism in association with polyendocrine autoimmunity

Discussion

Member takes

Implication

Key Points

Cite This Study

Hyperthyroidism following primary hypothyroidism in association with polyendocrine autoimmunity

Discussion

Member takes

Implication

Key Points

Cite This Study

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