Key result
Esophageal balloon and electrical stimulation revealed slowing of afferent vagal conduction in two patients with diabetic gastroparesis, though good evoked potential responses were recorded.
Case Report (n=2)
Afferent vagal pathways are involved in severe diabetes mellitus with gastroparesis, though symptoms may be more related to motor vagal impairment.
Answers are grounded in this paper and cite their sources.
May implicate afferent vagal slowing in diabetic gastroparesis; hypothesis-generating and should not yet change practice.
Two patients, a 28-year-old male and a 70-year-old female, with chronic insulin dependent diabetes mellitus and evidence of autonomic neuropathy were studied using cortical evoked responses following esophageal balloon and electrical stimulation. Both patients had symptomatic gastroparesis, poor gastric emptying, and reduced gastroduodenal motility including abnormal results of scintigraphy and manometry. There was slowing of afferent vagal conduction but good evoked potential responses were recorded even though one patient could not feel electrical stimulation of either the proximal or distal esophagus. It is improbable that the gastric symptoms are due to an afferent autonomic neuropathy, but symptoms may well be related to impairment of motor vagal pathways. Nevertheless, afferent vagal pathways are involved in severe diabetes mellitus. The clinical significance of this delay in conduction velocity of afferent pathways remains to be established.
No takes yet. Share an insight, caveat, or question.
Tougas et al. (1992) conducted a case report in Diabetes Gastroparesis (n=2). Esophageal balloon and electrical stimulation was evaluated on Afferent vagal conduction and cortical evoked responses. Esophageal balloon and electrical stimulation revealed slowing of afferent vagal conduction in two patients with diabetic gastroparesis, though good evoked potential responses were recorded.
Synapse has enriched 10 related papers. Consider them for comparative context: