Incidence of Hepatic Metastases for Various Neoplasms in Several Strains of Mice

The incidence of hepatic metastases for a variety of spontaneous and carcinogen-induced malignant neoplasms was studied in several strains of mice. Forty percent of osteogenic sarcomas metastasized to the liver in C57BL/6 female mice. Fourteen percent of mesotheliomas metastasized to the liver in C3H mice and 11.5% of alveolar/bronchiolar carcinomas metastasized to the liver in BALB/c male mice. All other malignant neoplasms metastasized to the liver at a rate of less than 10% and most at less than 5%.