Key result
Patients with acute coronary syndrome had significantly increased CD147 gene expression (9.71-fold) compared to healthy controls (0.94-fold).
Why the study?
This study was conducted to evaluate the association of ACS with CD147 gene expression, lipid peroxidation, and antioxidants in an Egyptian population.
Case-Control (n=124)
No
Absolute Event Rate: 9.71% vs 0.94%
p-value: p=<0.001
CD147 gene expression is significantly elevated in acute coronary syndrome and correlates strongly with markers of myocardial injury, suggesting a potential role in plaque destabilization.
CD147/oxidative marker associations in ACS remain hypothesis-generating; larger prospective studies needed before clinical consideration.
Background The main mechanism of acute coronary syndrome (ACS) is the rupture of atherosclerotic plaques. Matrix metalloproteinases (MMPs) play an important role in the rupture of the vulnerable plaques. MMP secretion is stimulated by CD147, one of the immunoglobulin families. Malondialdehyde is an important marker of oxidative damage, which is related to the atherosclerotic process. Superoxide dismutase normally prevents the oxidative process. This study was conducted to evaluate the association of ACS with CD147 gene expression, lipid peroxidation, and antioxidants in Egyptian population. The study included 124 people, 62 ACS patients and 62 healthy controls. Results CD147 gene expression in the ACS group was significantly increased compared to the control group (p < 0.001). The ACS was 9.71 ± 3.56-fold; the control group was 0.94 ± 0.19-fold. Also, the SOD activity in the ACS group was significantly increased when compared to the control group (t = 16.023, p < 0.001). There was a highly significant increase in the MDA level in ACS groups when compared to the control group (t = 35.536, p < 0.001). There was a highly significant increase in the creatine kinase-MB (CK-MB) and high sensitive troponin I levels in ACS groups when compared to the control group (p < 0.001). Conclusion There is a highly significant positive correlation between CK-MB and CD147 in both control and ACS groups (p = <0.001**); also, there is highly significant positive correlation between high sensitive troponin I and CD 147 in both control and ACS groups (p = <0.001**), but we did not find significant correlation between SOD and CD147 or between MDA and CD 147 in both control and ACS groups.
No takes yet. Share an insight, caveat, or question.
Emam et al. (2020) conducted a case-control in Acute coronary syndrome (n=124). Acute coronary syndrome vs. Healthy controls was evaluated on CD147 gene expression fold change (p=<0.001). Patients with acute coronary syndrome had significantly increased CD147 gene expression (9.71-fold) compared to healthy controls (0.94-fold).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: