Why the study?
Oxidative stress and reactive oxygen species form advanced glycation end-products that are associated with ACS and may promote its development.
Are levels of oxidative stress biomarkers and advanced glycation end-products altered in patients with acute coronary syndrome compared to healthy controls?
Are levels of oxidative stress biomarkers and advanced glycation end-products altered in patients with acute coronary syndrome compared to healthy controls?
Increased serum concentrations of AGEs and oxidative markers, along with reduced antioxidants, are associated with acute coronary syndrome and may serve as potential biomarkers.
May signal oxidative stress in ACS; leaves open whether AGEs aid risk stratification or warrant targeted therapy.
Background: As a repercussion of oxidative stress, reactive oxygen species augment the biochemical reaction of amino and carbohydrate groups of proteins, thus forming oxidative products known as Advanced Glycation End-products (AGEs), associated with acute coronary syndrome (ACS). Together, this milieu provokes oxidative stress and promotes the development of ACS.Methods: The studied cohort had 76 ACS individuals and 76 healthy controls. Blood samples of both groups were collected to measure the concentration of AGEs, Malondialdehyde (MDA), and the activity of antioxidants. Levels of lipid profile and inflammatory biomarkers were accessed in the study. The spectrophotometric ELISA kit was used to determine the levels of parameters.Result: The results indicated a significant increase in AGEs, MDA, LDL, and total cholesterol levels. Increased inflammatory markers, Intercellular adhesion molecule 1, and vascular cell adhesion proteins-1 in ACS patients were compared with the control subjects. A decrease is recorded in superoxide dismutase, HDL, and glutathione levels in ACS individuals.Conclusion: Our study demonstrated increased serum concentration of AGEs and several other factors, such as increased oxidative markers and, conversely, reduction in the antioxidant in ACS individuals. Therefore, we conclude these variables can be a potential biomarker in ACS individuals.
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Malik et al. (2023) studied this question.
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