Key result
CKD linked to higher AGEs and sRAGE versus abdominal aortic aneurysms and aortoiliac occlusive disease.
Why the study?
The study aimed to identify the relationship between AGEs, sRAGE, the AGEs/sRAGE ratio, and uric acid levels across different atherosclerosis-related diseases differing in oxidative stress intensity.
Observational (n=175)
Different atherosclerosis-related diseases exhibit distinct profiles of advanced glycation end products and uric acid, reflecting varying intensities of oxidative stress.
CKD-linked AGE/sRAGE elevations suggest disease-specific oxidative stress; hypothesis-generating and should not yet change practice.
Our study aimed to identify the relationship between advanced glycation end products (AGEs), soluble receptor for advanced glycation end products (sRAGE), the AGEs/sRAGE, and uric acid (UA) levels in selected atherosclerosis diseases, i.e., abdominal aortic aneurysms (AAA), aortoiliac occlusive disease (AIOD), and chronic kidney disease (CKD), resulting from apparent differences in oxidative stress intensity. Furthermore, we suggest that increased AGEs levels may stimulate an antioxidant defense system reflected by the UA level. The studied group size consisted of 70 AAA patients, 20 AIOD patients, 50 patients in the pre-dialyzed group (PRE), and 35 patients in the hemodialyzed group (HD). The enzyme-linked immunosorbent assay was used to measure AGEs and sRAGE levels. We found a significantly higher concentration of AGEs in CKD patients as compared to AAA and AIOD patients. Furthermore, the sRAGE level was higher in the CKD patients in comparison to AIOD and AAA patients. UA level was significantly higher in the PRE group compared to AAA patients. In conclusion, the diseases included in this study differ in the anti- and prooxidant defense system, which is reflected in the relations between the AGEs, the sRAGE, the AGEs/sRAGE ratio, as well as the UA levels.
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Gryszczyńska et al. (2020) conducted an observational in Atherosclerosis-related diseases (AAA, AIOD, CKD) (n=175). Chronic kidney disease vs. Abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AIOD) was evaluated on Levels of advanced glycation end products (AGEs), sRAGE, AGEs/sRAGE ratio, and uric acid. Chronic kidney disease was associated with significantly higher concentrations of AGEs and sRAGE compared to abdominal aortic aneurysms and aortoiliac occlusive disease.
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