Key result
Patients with acute coronary syndrome had significantly elevated levels of oxidative and inflammatory markers, including MMP-11 (96.35 vs 41.59 ng/ml, p=0.001), compared to healthy controls.
Why the study?
Evaluating patients presenting with chest pain or acute coronary syndrome signs is time-consuming, expensive, and challenging, while raised biomarkers can provide an initial outlook of risk.
Are oxidative stress and inflammatory biomarkers elevated in patients with acute coronary syndrome compared to healthy controls?
Case-Control (n=132)
No
Are oxidative stress and inflammatory biomarkers elevated in patients with acute coronary syndrome compared to healthy controls?
Oxidative stress and inflammatory biomarkers are significantly elevated in patients with acute coronary syndrome, suggesting a supportive pathogenic role in plaque destabilization.
BACKGROUND: Patient approaching hospital with the chest pain or other acute coronary syndrome signs or symptoms evaluation is time taking, pricey, complex and challenging.Raised biomarkers of necrosis including oxidative stress, cytokines, cell adhesive molecules, biomarker of destabilization of formed plaque and rupture, ischemia biomarkers and myocardial stretch biomarker endow initial outlook of patient's overall risk and also be familiar with high risk patients of adverse events.METHODOLOGY: Different biomarkers of AGEs, AOPPs, lipid biomarkers, and inflammatory markers among 132 control and acute coronary syndrome patient's serum samples via different lab tests and ELIZA kits were assessed.The results were analyzed by independent ttest in SPSS version 21.RESULTS: Significantly increasing trends of MDA (0.911±0.033 nmol/ml vs. 4.19±1.09nmol/ml), NO (20.59±1.89ng/ml vs. 81.25±5.19ng/ml),AGEs (0.61±0.014 ng/ml vs. 4.19±0.48ng/ml) and AOPPs (95.65±5.19ng/ml vs. 133.26±10.32ng/ml)was depicted in patients of ACS
No takes yet. Share an insight, caveat, or question.
A 2021 study conducted a case-control in Acute Coronary Syndrome (n=132). Acute Coronary Syndrome vs. Healthy controls was evaluated on MMP-11 levels (ng/ml) (p=0.001). Patients with acute coronary syndrome had significantly elevated levels of oxidative and inflammatory markers, including MMP-11 (96.35 vs 41.59 ng/ml, p=0.001), compared to healthy controls.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: